Development of mucoadhesive patches containing alpha-mangostin for aphthous ulcers

Abstract

This study aimed to develop alpha-mangostin (α-MN) loaded mucoadhesive patches for aphthous ulcers and investigates their physicochemical properties. Patches, prepared by solvent casting method, consisted of an ethylcellulose backing layer supporting a mucoadhesive gelatin layer loaded with α-MN. For mucoadhesive layer, the higher gelatin bloom strength correlated with increased puncture strength and elongation at break. Notably, the 300-bloom gelatin exhibited superior mechanical characteristics. However, the introduction of glycerin as a plasticizer resulted in decreased puncture strength without any significant increase in elongation at the break. Furthermore, an escalation in gelatin concentration from 1% to 7% increased patch thickness and puncture strength. Importantly, increasing gelatin concentration correlated with an extended in vitro residence time. Successful loading of α-MN into the patches was achieved in a range of 144.12 ± 27.10 to 441.05 ± 94.79 μg/cm2 At optimal conditions, the prepared patch exhibited good mechanical strength and flexibility. It demonstrated an ability to adhere to mucous membranes for up to 8 hours, serving as a potential aid in concealing wounds while ensuring sustained release of α-MN. These findings demonstrate the successful development of mucoadhesive patches with promising properties for potential oral mucosal drug delivery applications. This research lays the foundation for further optimization and advancement in the development of mucoadhesive patches, offering potential solutions for various oral mucosal diseases

This study aimed to develop alpha-mangostin (α-MN) loaded mucoadhesive patches for aphthous ulcers and investigates their physicochemical properties. Patches, prepared by solvent casting method, consisted of an ethylcellulose backing layer supporting a mucoadhesive gelatin layer loaded with α-MN. For mucoadhesive layer, the higher gelatin bloom strength correlated with increased puncture strength and elongation at break. Notably, the 300-bloom gelatin exhibited superior mechanical characteristics. However, the introduction of glycerin as a plasticizer resulted in decreased puncture strength without any significant increase in elongation at the break. Furthermore, an escalation in gelatin concentration from 1% to 7% increased patch thickness and puncture strength. Importantly, increasing gelatin concentration correlated with an extended in vitro residence time. Successful loading of α-MN into the patches was achieved in a range of 144.12 ± 27.10 to 441.05 ± 94.79 μg/cm2 At optimal conditions, the prepared patch exhibited good mechanical strength and flexibility. It demonstrated an ability to adhere to mucous membranes for up to 8 hours, serving as a potential aid in concealing wounds while ensuring sustained release of α-MN. These findings demonstrate the successful development of mucoadhesive patches with promising properties for potential oral mucosal drug delivery applications. This research lays the foundation for further optimization and advancement in the development of mucoadhesive patches, offering potential solutions for various oral mucosal diseases.